| T8330 |
BIO-013077-01
|
746667-48-1
|
98%
|
|
|
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
|
| T3636 |
(E)-SIS3
|
521984-48-5
|
98%
|
|
|
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or P...
|
| T1748 |
Kartogenin
|
4727-31-5
|
98%
|
|
|
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
|
| T1449 |
Hydrochlorothiazide
|
58-93-5
|
98%
|
|
|
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
|
| T36680 |
SM1-71
|
2088179-99-9
|
98%
|
|
|
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...
|
| T41245 |
Trimethylamine N-oxide
|
1184-78-7
|
98%
|
|
|
Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in ti...
|
| T24897 |
TP0427736
|
864374-00-5
|
98%
|
|
|
TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF...
|
| T77019 |
Garetosmab
|
2097125-54-5
|
98%
|
Garetosmab
|
|
Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cance...
|
| T76941 |
Carotuximab
|
1268714-50-6
|
98%
|
Carotuximab
|
|
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD10...
|
| T76863 |
Elezanumab
|
1791416-49-3
|
98%
|
|
|
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 ...
|
| T76858 |
Ascrinvacumab
|
1463459-96-2
|
98%
|
Ascrinvacumab
|
|
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ...
|
| T76774 |
Ponsegromab
|
2368950-15-4
|
98%
|
Ponsegromab
|
|
Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor. Ponsegromab has anti-cachexic activity by binding to GDF15 to pre...
|
| T76681 |
Fresolimumab
|
948564-73-6
|
98%
|
Fresolimumab
|
|
Fresolimumab (GC1008) is a specific human anti-transforming growth factor β monoclonal antibody that binds to the active forms of human TGFβ1, TGFβ2, and TGFβ3 a...
|
| T5197 |
BIBF0775
|
334951-90-5
|
98%
|
|
|
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
|
| T20319 |
Pentabromophenol
|
608-71-9
|
98%
|
|
|
Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.
|
| T60644 |
SJ000063181
|
945189-68-4
|
98%
|
|
|
SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ...
|
| T7676 |
LSKL, Inhibitor of Thrombospondin TSP-1 acetate
|
T7676
|
|
|
|
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
|
| T61301 |
Chromenone 1
|
1639929-29-5
|
100%
|
|
|
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedbac...
|
| T11052L |
Disitertide acetate
|
|
95.11%
|
|
|
Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its rec...
|
| T2510 |
Galunisertib
|
700874-72-2
|
97.09%
|
|
|
Galunisertib (LY2157299) is an orally available inhibitor of TGFβRI kinase (IC50: 56 nM) with potential antineoplastic activity.
|
