| T12923 |
SIS3 free base
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SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
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| T7377 |
LSKL, Inhibitor of Thrombospondin (TSP-1)
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LSKL, Inhibitor of Thrombospondin (TSP-1) is a peptide derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-β.
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| T35348 |
LDN-193189 2HCl
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| TN3753 |
Dalbergioidin
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Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
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| T13137 |
TGFβRI-IN-1
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TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
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| T61301 |
Chromenone 1
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Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedbac...
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| T20319 |
Pentabromophenol
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Pentabromophenol inhibits TGF-β signaling by accelerating the degradation of type II TGF-β receptors via caveolae-mediated endocytosis.
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| T24897 |
TP0427736
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TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF...
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| T9523 |
TGFβRI-IN-3
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TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has poten...
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| T12433 |
PF-06952229
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PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
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| T7676 |
LSKL, Inhibitor of Thrombospondin TSP-1 acetate
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LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
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| T11052L |
Disitertide acetate
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Disitertide acetate is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitert...
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| T1748 |
Kartogenin
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Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
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| T3524 |
Halofuginone hydrobromide
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Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
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| T6856 |
Halofuginone
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Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase（Ki=18.3 nM）, could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
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| T3031 |
A 83-01
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A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 n...
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| T2109 |
SD-208
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SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
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| T1800 |
GW788388
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GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
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| T8730 |
BMS986260
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BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
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| T2565 |
Hesperetin
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Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges....
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| T6337 |
RepSox
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RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
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| T3636 |
(E)-SIS3
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SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signali...
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| TQ0184 |
Chebulinic acid
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Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
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| T1935 |
LDN193189
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LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6)....
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| T4283 |
SRI-011381
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SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
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| T6324 |
BIX02188
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BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
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| T4662 |
SJ000291942
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SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
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| T1900 |
LDN-212854
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LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus...
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| T5197 |
BIBF0775
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BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
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| T5125 |
LY3200882
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LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
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| T1977 |
Dorsomorphin
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Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
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| T2896 |
Alantolactone
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Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transdu...
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| T2098 |
A 77-01
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A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
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| T2803 |
Monocrotaline
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Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other ...
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| T5129 |
SRI-011381 hydrochloride
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SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
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| T3924 |
Astragaloside II
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Astragaloside II is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteog...
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| T1943 |
ML347
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ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
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| T3025 |
Asiaticoside
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Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burn...
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| T16708 |
R-268712
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R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
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| T6496 |
Vactosertib
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Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as act...
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| TN1040 |
Skullcapflavone II
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Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavon...
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| T4975 |
SM 16
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SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
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| T1914 |
K02288
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K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
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| T8785 |
HALOFUGINONE LACTATE
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HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone ...
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| T2123 |
LY2109761
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LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosph...
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| T2754 |
Oxymatrine
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Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis ...
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| T1944 |
LDN-214117
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LDN-214117 is a potent and selective ALK2 inhibitor.
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| T2416 |
BIX02189
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BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
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| T1763 |
SB 525334
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SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
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| T1726 |
SB-431542
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SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
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