TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.

Cat. No.	製品名	CAS No.	Purity
TQ0184	Chebulinic acid	18942-26-2	98%
TQ0184	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T4283	SRI-011381	1629138-41-5	98%
T4283	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T10572L	BMT-124110 Formate	T10572L	98%
T10572L	BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase ...
T6324	BIX02188	1094614-84-2	98%
T6324	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
T4662	SJ000291942	425613-09-8	98%
T4662	SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
T9947	GW-6604	452342-37-9	98%
T9947	GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
T73300	AXL-IN-13	2376928-82-2	98%
T73300	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
T1900	LDN-212854	1432597-26-6	98%
T1900	LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus...
T62483	CJJ300	1807631-83-9	98%
T62483	CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II ...
T5197	BIBF0775	334951-90-5	98%
T5197	BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
T12433	PF-06952229	1801333-55-0	98%
T12433	PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
T5125	LY3200882	1898283-02-7	98%
T5125	LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T1977	Dorsomorphin	866405-64-3	98%
T1977	Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T10287	ALK2-IN-2	2254409-25-9	98%
T10287	ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.
T2098	A 77-01	607737-87-1	98%
T2098	A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T5129	SRI-011381 hydrochloride	2070014-88-7	98%
T5129	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T2803	Monocrotaline	315-22-0	98%
T2803	Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other ...
T3924	Astragaloside II	84676-89-1	98%
T3924	Astragaloside II is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteog...
T1943	ML347	1062368-49-3	98%
T1943	ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T3025	Asiaticoside	16830-15-2	98%
T3025	Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burn...