| T39669 |
TLR7/8/9-IN-1
|
2180127-82-4
|
98%
|
|
|
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
|
| T19675 |
SM360320
|
226907-52-4
|
98%
|
|
|
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addit...
|
| T39654 |
Afimetoran
|
2171019-55-7
|
98%
|
|
|
Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
|
| T35593 |
Semapimod tetrahydrochloride
|
164301-51-3
|
98%
|
|
|
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine produ...
|
| T76975 |
Tomaralimab
|
1449294-76-1
|
98%
|
Tomaralimab
|
|
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).
|
| T76089 |
Pepinh-TRIF TFA
|
|
98%
|
|
|
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction )....
|
| T15371 |
Gardiquimod
|
1020412-43-4
|
98%
|
|
|
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
|
| T15017 |
CU-T12-9
|
1821387-73-8
|
98%
|
|
|
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines...
|
| T60052 |
BMS-905
|
2205846-49-5
|
98%
|
|
|
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
|
| T8503 |
TLR4-IN-C34
|
40592-88-9
|
|
|
|
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
|
| T3795 |
Corilagin
|
23094-69-1
|
|
|
|
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
|
| T23171 |
Polyinosinic-polycytidylic acid
|
24939-03-5
|
|
|
|
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mamm...
|
| T11598 |
IAXO-102
|
1115270-63-7
|
|
|
|
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
|
| T12516 |
Polyinosinic-polycytidylic acid sodium
|
42424-50-0
|
|
|
|
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic...
|
| TP1938L |
RS09 2TFA (1449566-36-2 free base)
|
TP1938L
|
100%
|
|
|
RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in...
|
| T34249 |
Rabeximod
|
872178-65-9
|
100%
|
|
|
Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by ...
|
| TJS1779 |
Protosappanin A
|
102036-28-2
|
100%
|
|
|
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
|
| T3898 |
Schaftoside
|
51938-32-0
|
100%
|
|
|
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
|
| T77353 |
MyD88-IN-1
|
2911609-80-6
|
100%
|
|
|
MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pat...
|
| T9645 |
CU-115
|
2471982-20-2
|
100%
|
|
|
CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β...
|
