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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T3790 Hederacoside D 760961-03-3 98%
Hederacoside D is a bioactive saponins from Hedera helix.
T3123 Allicin 539-86-6 98%
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cel...
TN1507 Clematichinenoside AR 761425-93-8 98%
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associate...
T37445 Etanercept 185243-69-0 98%
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β ...
T3805 Prim-O-glucosylcimifugin 80681-45-4 98%
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/...
T36524 IKK2-IN-4 354811-10-2 98%
IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
T2S1040 Jolkinolide B 37905-08-1 98%
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T4403 AX-024 hydrochloride 1704801-24-0 98%
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TN...
T60657 (R)-STU104 2767124-77-4 98%
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathwa...
T0213 Thalidomide 50-35-1 98%
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-...
TN1936 Mogroside III-E 88901-37-5 98%
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
T6S0653 Linarin 480-36-4 98%
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviate...
TN2079 (-)-Pinoresinol 81446-29-9 98%
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
T26326 VU0285655-1 1158347-73-9 98%
VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhib...
T5S0993 Kurarinone 34981-26-5 98%
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T1813 VGX-1027 6501-72-0 98%
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
T3426 Bacoside A 11028-00-5 98%
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
T14381 AZD7624 1095004-78-6 98%
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
T77484 Atibuclimab 2417175-94-9 98%
Atibuclimab
Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat ...
T77138 Ragifilimab 2207590-51-8 98%
Ragifilimab
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting glucocorticoid-induced TNFR-associated protein (GITR). Ragifilimab can be used in the study...
Hederacoside D
T3790
Hederacoside D is a bioactive saponins from Hedera helix.
Allicin
T3123
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cel...
Clematichinenoside AR
TN1507
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associate...
Etanercept
T37445
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β ...
Prim-O-glucosylcimifugin
T3805
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/...
IKK2-IN-4
T36524
IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
Jolkinolide B
T2S1040
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
AX-024 hydrochloride
T4403
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TN...
(R)-STU104
T60657
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathwa...
Thalidomide
T0213
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-...
Mogroside III-E
TN1936
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
Linarin
T6S0653
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviate...
(-)-Pinoresinol
TN2079
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
VU0285655-1
T26326
VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhib...
Kurarinone
T5S0993
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
VGX-1027
T1813
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
Bacoside A
T3426
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
AZD7624
T14381
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
Atibuclimab
T77484
Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat ...
Ragifilimab
T77138
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting glucocorticoid-induced TNFR-associated protein (GITR). Ragifilimab can be used in the study...
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