| T6057 |
URMC-099
|
1229582-33-5
|
98%
|
|
|
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
|
| T19649 |
PF-06273340
|
1402438-74-7
|
98%
|
|
|
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metab...
|
| T6052 |
GW 441756
|
504433-23-2
|
98%
|
|
|
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
|
| T14363 |
AZ-23
|
915720-21-7
|
98%
|
|
|
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM,...
|
| T0678 |
Amitriptyline hydrochloride
|
549-18-8
|
98%
|
|
|
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive ...
|
| T9496 |
LOXO-195
|
1350884-56-8
|
98%
|
|
|
(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.
|
| T62447 |
Paltimatrectinib
|
2353522-15-1
|
98%
|
|
|
Paltimatrectinib (PBI-200) is a potent tyrosine kinase inhibitor with anticancer activity that inhibits myosin-related kinase A (TrkA).Paltimatrectinib is used i...
|
| T2054 |
Altiratinib
|
1345847-93-9
|
98%
|
|
|
Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, c...
|
| T5995 |
Larotrectinib
|
1223403-58-4
|
100%
|
|
|
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).
|
| T1704 |
Diosmetin
|
520-34-3
|
100%
|
|
|
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
|
| T7435 |
Selitrectinib
|
2097002-61-2
|
95.49%
|
|
|
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively)
|
| T9292 |
ALE-0540
|
234779-34-1
|
97.25%
|
|
|
ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediate...
|
| T7568 |
LM22A-4
|
37988-18-4
|
98%
|
|
|
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anis...
|
| T5635 |
CH7057288
|
2095616-82-1
|
98%
|
|
|
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
|
| T1354 |
N-Acetyl-5-hydroxytryptamine
|
1210-83-9
|
98.03%
|
|
|
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the en...
|
| T4496 |
LM22B-10
|
342777-54-2
|
98.19%
|
|
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
|
| T41224 |
CG 428
|
2412055-93-5
|
98.26%
|
|
|
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 jo...
|
| T8327 |
ONO-7475
|
1646839-59-9
|
98.33%
|
|
|
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
|
| T6121 |
Tepotinib
|
1100598-32-0
|
98.35%
|
|
|
Tepotinib (EMD-1214063) is an inhibitor of MET tyrosine kinase with potential antineoplastic activity.
|
| T2816 |
7,8-Dihydroxyflavone
|
38183-03-8
|
98.37%
|
|
|
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.
|
