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Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Cat. No. 製品名 CAS No. Purity Chemical Structure
T6309 AZ960 905586-69-8 98%
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
T1776L Plerixafor octahydrochloride 155148-31-5 98%
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting ...
T25770 116-9e 831217-43-7 98%
116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumo...
T16702 QL47 1469988-75-7 98%
QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translatio...
T5158 N-Desmethylclozapine 6104-71-8 98%
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 re...
T38399 (Rac)-Golgicide A 1005036-73-6 98%
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.
T8328 STING agonist-1 702662-50-8 98%
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
T13397 ZINC03129319 1777807-64-3 98%
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.
T6605 NH125 278603-08-0 98%
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T11281L FGI-106 tetrahydrochloride 1149348-10-6 98%
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, ...
TN1480 Cephaeline 483-17-0 98%
Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeo...
T77423 Lirilumab 1000676-41-4 98%
Lirilumab
Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical c...
T76856 Andecaliximab 1518996-49-0 98%
Andecaliximab
Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model o...
T76690 Mavrilimumab 1085337-57-0 98%
Mavrilimumab
Mavrilimumab (CAM 3001) is a monoclonal antibody with antiviral activity that has an affinity for the α subunit of the granulocytic-macrophage colony-stimulating...
T4850 PCL 016 98-98-6 98%
PCL 016 (2-Picolinic acid) is a topical antiviral agent, which inhibits adenovirus replication in rabbit.
T5013 Brequinar 96187-53-0 98%
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
TN6508 Trachelogenin 34209-69-3 98%
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to aff...
T61334 DMA-135 hydrochloride 2237925-62-9 98%
DMA-135 hydrochloride (DMA-135 HCl) Antivirally active compounds that target RNA and inhibit enterovirus type 71 (EV71) IRES-dependent translation and replicatio...
T8205 Norwogonin 4443-09-8 98%
Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).
T5886 4-Phenylbutyric acid 1821-12-1 98%
4-Phenylbutyric acid (Benzenebutyric acid) is an inhibitor of HDAC,and is an antineoplastic agent.
AZ960
T6309
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
Plerixafor octahydrochloride
T1776L
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting ...
116-9e
T25770
116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumo...
QL47
T16702
QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translatio...
N-Desmethylclozapine
T5158
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 re...
(Rac)-Golgicide A
T38399
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.
STING agonist-1
T8328
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
ZINC03129319
T13397
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.
NH125
T6605
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
FGI-106 tetrahydrochloride
T11281L
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, ...
Cephaeline
TN1480
Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeo...
Lirilumab
T77423
Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical c...
Andecaliximab
T76856
Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model o...
Mavrilimumab
T76690
Mavrilimumab (CAM 3001) is a monoclonal antibody with antiviral activity that has an affinity for the α subunit of the granulocytic-macrophage colony-stimulating...
PCL 016
T4850
PCL 016 (2-Picolinic acid) is a topical antiviral agent, which inhibits adenovirus replication in rabbit.
Brequinar
T5013
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
Trachelogenin
TN6508
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to aff...
DMA-135 hydrochloride
T61334
DMA-135 hydrochloride (DMA-135 HCl) Antivirally active compounds that target RNA and inhibit enterovirus type 71 (EV71) IRES-dependent translation and replicatio...
Norwogonin
T8205
Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).
4-Phenylbutyric acid
T5886
4-Phenylbutyric acid (Benzenebutyric acid) is an inhibitor of HDAC,and is an antineoplastic agent.
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