| T35610 |
2,5-dimethyl Celecoxib
|
457639-26-8
|
98%
|
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
|
| T4468 |
WAY 316606
|
915759-45-4
|
98%
|
|
|
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
|
| T31987 |
Gossypolone
|
4547-72-2
|
98%
|
|
|
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
|
| T4043 |
ETC-159
|
1638250-96-0
|
98%
|
|
|
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
|
| TL0007 |
Bisdemethoxycurcumin
|
24939-16-0
|
98%
|
|
|
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-d...
|
| T5636 |
Adavivint
|
1467093-03-3
|
98%
|
|
|
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
|
| T1807 |
JW 55
|
664993-53-7
|
98%
|
|
|
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2)...
|
| T15469 |
Hematein
|
475-25-2
|
98%
|
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|
| T77660 |
TINK-IN-1
|
1417795-25-5
|
98%
|
|
|
TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.
|
| T9988 |
Wnt/β-catenin agonist 3
|
912790-59-1
|
98%
|
|
|
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
|
| T2702 |
IWP-2
|
686770-61-6
|
98%
|
|
|
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
|
| TN6508 |
Trachelogenin
|
34209-69-3
|
98%
|
|
|
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to aff...
|
| T2161 |
Cardiogenol C
|
671225-39-1
|
98%
|
|
|
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
|
| T22884 |
JW 67
|
442644-28-2
|
98%
|
|
|
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including ...
|
| T27582 |
ICRT-5
|
18623-44-4
|
98%
|
|
|
iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be u...
|
| T3168 |
MN-64
|
92831-11-3
|
98%
|
|
|
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
|
| T6113 |
ICG-001
|
780757-88-2
|
98%
|
|
|
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
|
| T9696 |
β-catenin-IN-2
|
1458664-10-2
|
98%
|
|
|
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
|
| T9557 |
TNIK-IN-2
|
2754265-76-2
|
98%
|
|
|
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
|
| T4486 |
ICRT 14
|
677331-12-3
|
98%
|
|
|
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
|
