| T14149 |
AICAR phosphate
|
681006-28-0
|
98%
|
|
|
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...
|
| T60148 |
MSC-4106
|
2738542-58-8
|
100%
|
|
|
MSC-4106, an orally active and potent YAP/TAZ-TEAD inhibitor, disrupts TEAD1 and TEAD3 auto-palmitoylation and demonstrates significant efficacy in the NCI-H226 ...
|
| T9053 |
Lats-IN-1
|
1424635-83-5
|
97.54%
|
|
|
Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
|
| T3112 |
Verteporfin
|
129497-78-5
|
98.03%
|
|
|
Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also...
|
| T1477 |
AICAR
|
2627-69-2
|
98.21%
|
|
|
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treat...
|
| T35545 |
VT107
|
2417718-63-7
|
98.43%
|
|
|
VT107 is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].
|
| T62077 |
VT103
|
2290608-13-6
|
98.73%
|
|
|
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting...
|
| T64342 |
DC-TEADin02
|
2380228-45-3
|
98.82%
|
|
|
DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
|
| T60218 |
YAP/TAZ inhibitor-2
|
2762617-31-0
|
98.84%
|
|
|
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor ...
|
| T77580 |
IK-930
|
2563892-44-2
|
98.86%
|
|
|
IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
|
| T69760 |
TT-10
|
2230640-94-3
|
99.29%
|
|
|
TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease re...
|
| T9566 |
PY-60
|
2765218-56-0
|
99.32%
|
|
|
PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional pro...
|
| T22372 |
MYF-01-37
|
2416417-65-5
|
99.46%
|
|
|
MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.
|
| T67872 |
VT104
|
2417718-25-1
|
99.5%
|
|
|
VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.
|
| TP2160L1 |
YAP-TEAD-IN-1 acetate
|
TP2160L1
|
99.57%
|
|
|
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.
|
| T77729 |
MY-1076
|
3008262-76-5
|
99.57%
|
|
|
MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and ...
|
| T3050 |
ML-7 hydrochloride
|
110448-33-4
|
99.61%
|
|
|
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also...
|
| T8421 |
TED-347
|
2378626-29-8
|
99.91%
|
|
|
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
|
| T72888 |
YAP-TEAD-IN-2
|
2714432-83-2
|
98%
|
|
|
YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) va...
|
| T81056 |
SWTX-143
|
2766575-48-6
|
98%
|
|
|
SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional ...
|
