T35384 |
TPX-0046
|
2359650-19-2
|
98%
|
|
TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.
|
T6028 |
PF 477736
|
952021-60-2
|
98%
|
|
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
|
T5171 |
Treprostinil Sodium
|
289480-64-4
|
98%
|
|
Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
|
T69644 |
DUN73423
|
2414373-42-3
|
98%
|
|
DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.
|
T6982 |
SGI-7079
|
1239875-86-5
|
98%
|
|
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR...
|
T9673 |
RET-IN-3
|
2414374-53-9
|
98%
|
|
RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.
|
T5491 |
GSK3179106
|
1627856-64-7
|
98%
|
|
GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM
|
T8222 |
Selpercatinib
|
2152628-33-4
|
100%
|
|
Selpercatinib (LOXO-292) is a tyrosine kinase inhibitor with antineoplastic properties(IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET...
|
T8402 |
Regorafenib Hydrochloride
|
835621-07-3
|
100%
|
|
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with pote...
|
T7418 |
BBT594
|
882405-89-2
|
96.56%
|
|
BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.
|
T8467 |
RET V804M-IN-1
|
2414909-94-5
|
96.97%
|
|
RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
|
T2032 |
WHI-P180
|
211555-08-7
|
97.74%
|
|
WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
|
T2282 |
RPI-1
|
269730-03-2
|
98%
|
|
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
|
T2358 |
ENMD-2076
|
934353-76-1
|
98%
|
|
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
|
T10157 |
Regorafénib N-oxyde (M2)
|
835621-11-9
|
98.03%
|
|
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
|
TQ0059 |
Ilorasertib
|
1227939-82-3
|
98.03%
|
|
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It als...
|
T22349 |
JNJ-38158471
|
951151-97-6
|
98.04%
|
|
JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such ...
|
TQ0277 |
Pralsetinib
|
2097132-94-8
|
98.1%
|
|
Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and...
|
T4053 |
AST 487
|
630124-46-8
|
98.17%
|
|
AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
|
T16923 |
SPP-86
|
1357349-91-7
|
98.19%
|
|
SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.
|