| T9698 |
UC2288
|
1394011-91-6
|
98%
|
|
|
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein sta...
|
| T3184 |
Kevetrin hydrochloride
|
66592-89-0
|
98%
|
|
|
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineo...
|
| T37042 |
SCH529074
|
922150-11-6
|
98%
|
|
|
SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and ...
|
| T60839 |
SLMP53-1
|
1643469-17-3
|
98%
|
|
|
SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, a...
|
| TN4583 |
Moringin
|
73255-40-0
|
98%
|
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
|
| T77768 |
BAY 1892005
|
2036352-13-1
|
98%
|
|
|
BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein
|
| T7703 |
PK11007
|
874146-69-7
|
|
|
|
PK11007 is an anti-p53 drug.
|
| TQ0133 |
Amifostine thiol dihydrochloride
|
14653-77-1
|
100%
|
|
|
Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of ...
|
| T8480 |
Tenovin-6 Hydrochloride
|
1011301-29-3
|
100%
|
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
|
| T2947 |
Indole-3-carbinol
|
700-06-1
|
100%
|
|
|
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activatio...
|
| T3000 |
Magnolol
|
528-43-8
|
100%
|
|
|
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
|
| T24730 |
Roslin 2 bromide
|
29574-21-8
|
97.07%
|
|
|
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
|
| T2243 |
Serdemetan
|
881202-45-5
|
97.13%
|
|
|
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
|
| TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
| T3375 |
Verbascoside
|
61276-17-3
|
97.46%
|
|
|
Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
|
| T2464 |
ZMC1
|
71555-25-4
|
97.48%
|
|
|
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
|
| T41068 |
P53R3
|
922150-12-7
|
97.56%
|
|
|
P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R...
|
| T1798 |
RITA
|
213261-59-7
|
97.76%
|
|
|
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt t...
|
| T4126 |
CBL0137
|
1197996-80-7
|
98%
|
|
|
CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilita...
|
| T16771 |
RO-5963
|
1416663-77-8
|
98%
|
|
|
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
|
